Flow chemistry technology is a powerful tool to boost the efficiency and ease the scalability of modern synthetic strategies. We present herein an adaptation of a methodology for direct arylation of thiophenes in an automated flow system. Using a packed-bed reactor containing the inorganic base, the C−H functionalization was efficiently performed on a wide scope and up to the gram-scale.
Direct Arylation of Thiophenes in Continuous Flow
Tommaso Carofiglio;Paolo Zardi
2023
Abstract
Flow chemistry technology is a powerful tool to boost the efficiency and ease the scalability of modern synthetic strategies. We present herein an adaptation of a methodology for direct arylation of thiophenes in an automated flow system. Using a packed-bed reactor containing the inorganic base, the C−H functionalization was efficiently performed on a wide scope and up to the gram-scale.
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