Pr5-ALA has been well-established for use in intraoperative fluorescence-guided resection of malignant glioma. It is not as strongly supported for use with low-grade gliomas (LGG) because only a few of these, less than 20%, have visible porphyrin accumulation, which is useful for 5-ALA-guided surgery. We report here our experience with 5-ALA uptake in a case of suspected relapse of anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted. Fluorescence-guided surgery is one of the most significant innovations in the surgical management of HGG over the past decade. Nevertheless, 5-ALA-guided surgery is not yet feasible for most cases of LGG. To our knowledge, this is the first report of strong 5-ALA activation in non-tumoral or peritumoral tissue.
5-ALA False Positive in Anaplastic Oligodendroglioma, IDH-mutant and 1p/19q-codeleted
Ius T;
2020
Abstract
Pr5-ALA has been well-established for use in intraoperative fluorescence-guided resection of malignant glioma. It is not as strongly supported for use with low-grade gliomas (LGG) because only a few of these, less than 20%, have visible porphyrin accumulation, which is useful for 5-ALA-guided surgery. We report here our experience with 5-ALA uptake in a case of suspected relapse of anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted. Fluorescence-guided surgery is one of the most significant innovations in the surgical management of HGG over the past decade. Nevertheless, 5-ALA-guided surgery is not yet feasible for most cases of LGG. To our knowledge, this is the first report of strong 5-ALA activation in non-tumoral or peritumoral tissue.
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