Over the past 25 years, the Nolan group has advanced N-heterocyclic carbene (NHC) chemistry, establishing NHCs as versatile, stable ligands in organometallic science. Our research spans organometallic chemistry, homogeneous catalysis, medicinal chemistry, and photocatalysis. Key achievements include developing efficient NHC-metal catalysts for sustainable chemical transformations, designing NHC-metal complexes with potent anticancer activity, and introducing NHC-gold complexes for visible-light photocatalysis. These contributions highlight the broad impact of rational ligand design on catalysis, therapeutic innovation, and green chemistry.
N-Heterocyclic Carbenes as Game-Changing Ligands: Advances in Catalysis, Photocatalysis, and Medicinal Applications
Scattolin T.;
2025
Abstract
Over the past 25 years, the Nolan group has advanced N-heterocyclic carbene (NHC) chemistry, establishing NHCs as versatile, stable ligands in organometallic science. Our research spans organometallic chemistry, homogeneous catalysis, medicinal chemistry, and photocatalysis. Key achievements include developing efficient NHC-metal catalysts for sustainable chemical transformations, designing NHC-metal complexes with potent anticancer activity, and introducing NHC-gold complexes for visible-light photocatalysis. These contributions highlight the broad impact of rational ligand design on catalysis, therapeutic innovation, and green chemistry.
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