The interaction between NTA and soluble Cr(VI) (K2Cr 207) was studied by the Ames test on S. typhimurium and the sex-linked recessive lethal test on D. melanogaster. In both systems a synergistic efTect of NTA on Cr(VI) mutagenicity took place at sub-toxic doses of Cr(VI). The synergism could depend on the action of NTA on intracellular Cr(VI) reduction, as more Cr(VI) was reduced in vitro to Cr(III) by Salmonella and Drosophila protein extracts in the presence of NTA. A similar enhancement of soluble Cr(VI) mutagenicity was produced by low doses of EDTA.

Induction of gene mutations in Salmonella and in Drosophila by soluble Cr(VI) compounds: synergistic effects of nitrilotriacetic acid.

COSTA, RODOLFO;ZORDAN, MAURO AGOSTINO;VENIER, PAOLA;BIANCHI, VERA;LEVIS, ANGELO GINO
1989

Abstract

The interaction between NTA and soluble Cr(VI) (K2Cr 207) was studied by the Ames test on S. typhimurium and the sex-linked recessive lethal test on D. melanogaster. In both systems a synergistic efTect of NTA on Cr(VI) mutagenicity took place at sub-toxic doses of Cr(VI). The synergism could depend on the action of NTA on intracellular Cr(VI) reduction, as more Cr(VI) was reduced in vitro to Cr(III) by Salmonella and Drosophila protein extracts in the presence of NTA. A similar enhancement of soluble Cr(VI) mutagenicity was produced by low doses of EDTA.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/123694
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