The inactivation by a number of benzo and tetrahydrobenzopsoralen derivatives has been studied both by UVA irradiation and by simple incubation in the dark. Upon UVA irradiation the most active compounds appeared to be the 4-hydroxymethyl derivatives. After 3 hours of incubation in the dark all derivatives affected T2 infectivity. This dark effect could be related to a damage to the sensitive phage receptors necessary for its absorption on the bacterial surface.
New benzopsoralen derivatives: T2 phage inactivation.
BACCICHETTI, FRANCAROSA;MARZANO, CRISTINA;CARLASSARE, FRANCESCO;CHILIN, ADRIANA;BORDIN, FRANCO
1995
Abstract
The inactivation by a number of benzo and tetrahydrobenzopsoralen derivatives has been studied both by UVA irradiation and by simple incubation in the dark. Upon UVA irradiation the most active compounds appeared to be the 4-hydroxymethyl derivatives. After 3 hours of incubation in the dark all derivatives affected T2 infectivity. This dark effect could be related to a damage to the sensitive phage receptors necessary for its absorption on the bacterial surface.
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