Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors
MORO, STEFANO;COZZA, GIORGIO;PAGANO, MARIO ANGELO PRIMO;ZAGOTTO, GIUSEPPE;CHILIN, ADRIANA;GUIOTTO, ADRIANO;
2006
Abstract
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.File in questo prodotto:
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