In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Posttranslational Regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor Sigma(L) and roles in virulence and in global regulation of gene expression
DAINESE, ELISA;PROVVEDI, ROBERTA;PALU', GIORGIO;MANGANELLI, RICCARDO
2006
Abstract
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.File in questo prodotto:
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