One of the most harmful groups of coastal pollutants is the organotin compounds (OTCs) which have severe effects on both aquatic organisms and mammals including humans. The immunotoxic effects of OTCs were studied in the cultivated clam Tapes philippinarum by determining the immunosuppressant role on in vitro yeast phagocytosis at low doses (0.01, 0,05, 0.1 µM). The phagocytic index was significantly reduced in an irreversible non-lethal manner depending on concentration and lipophilic affinity. The order of inhibition was TBT>_DBT>MBT for butyltins and TPTC>TPTA_>_TPTH for triphenyltins.
Immunotoxic effects of organotin compounds in Tapes philippinarum
CIMA, FRANCESCA;MARIN, MARIA;MATOZZO, VALERIO;BALLARIN, LORIANO
1998
Abstract
One of the most harmful groups of coastal pollutants is the organotin compounds (OTCs) which have severe effects on both aquatic organisms and mammals including humans. The immunotoxic effects of OTCs were studied in the cultivated clam Tapes philippinarum by determining the immunosuppressant role on in vitro yeast phagocytosis at low doses (0.01, 0,05, 0.1 µM). The phagocytic index was significantly reduced in an irreversible non-lethal manner depending on concentration and lipophilic affinity. The order of inhibition was TBT>_DBT>MBT for butyltins and TPTC>TPTA_>_TPTH for triphenyltins.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
1998 Chemosphere.pdf
accesso aperto
Tipologia:
Published (Publisher's Version of Record)
Licenza:
Accesso gratuito
Dimensione
495.52 kB
Formato
Adobe PDF
|
495.52 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
