A structural feature of particular interest in order to get a better understanding of tissue perfusion is the way a pattern of growing vessels fills the available space. To address this point, we have developed automatic image analysis methods allowing a quantitative evaluation of several parameters (fractal dimension, lacunarity and nonfractal order–disorder parameters, such as positional, topological and orientational order) characterizing the level of spatial order/disorder exhibited by the vascular network of the CAM in basal conditions and after treatment for 96 h with an angiogenic cytokine, such as fibroblast growth factor-2 (FGF-2), or with an angiostatic molecule, such as vinblastine.
Order and disorder in the vascular network
GUIDOLIN, DIEGO;
2004
Abstract
A structural feature of particular interest in order to get a better understanding of tissue perfusion is the way a pattern of growing vessels fills the available space. To address this point, we have developed automatic image analysis methods allowing a quantitative evaluation of several parameters (fractal dimension, lacunarity and nonfractal order–disorder parameters, such as positional, topological and orientational order) characterizing the level of spatial order/disorder exhibited by the vascular network of the CAM in basal conditions and after treatment for 96 h with an angiogenic cytokine, such as fibroblast growth factor-2 (FGF-2), or with an angiostatic molecule, such as vinblastine.Pubblicazioni consigliate
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