Verapamil inhibited both the electrical and the mechanical activity of isolated guinea-pig taenia coli. The action of the drug was similar in some respects to that of quinidine as far as the electrical activity was concerned. Closer similarities were observed between it and diphenylhydantoin. The conclusion is drawn that the drug has points of attack at the electromechanical junction and the membrane.
[Effects of verapamil on the electrical and mechanical activity of smooth muscle].
MELACINI, PAOLA;
1975
Abstract
Verapamil inhibited both the electrical and the mechanical activity of isolated guinea-pig taenia coli. The action of the drug was similar in some respects to that of quinidine as far as the electrical activity was concerned. Closer similarities were observed between it and diphenylhydantoin. The conclusion is drawn that the drug has points of attack at the electromechanical junction and the membrane.
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