The interaction of cis- and trans-Pt(NH3)2Cl2 with DNAs of different base composition was studied by means of circular dichroism (CD) spectroscopy. The spectra obtained indicated a partial transformation of the secondary structure of DNA (B→C transition) with an increased helix winding. Subtle differences were noted between the two isomers, possibly related to changes in base orientation due to the different molecular geometries of the Pt(II) complexes. © 1977.
Interaction of Pt(II) complexes with DNAs from various sources. A circular dichroism study
CELOTTI, LUCIA;
1977
Abstract
The interaction of cis- and trans-Pt(NH3)2Cl2 with DNAs of different base composition was studied by means of circular dichroism (CD) spectroscopy. The spectra obtained indicated a partial transformation of the secondary structure of DNA (B→C transition) with an increased helix winding. Subtle differences were noted between the two isomers, possibly related to changes in base orientation due to the different molecular geometries of the Pt(II) complexes. © 1977.
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