The antimitotic and cytotoxic effects of cis-dichlorobis(cyclohexylamine)platinum(II) (cis-HAD) which among Pt complexes used as antitumoral drugs shows the highest therapeutic index (TI) have been compared to those of cis-dichlorodiamine platinum(II) (cis-DDP), the most commonly used drug of this group, using Chinese hamster ovary cell cultures (CHO line). DNA synthesis inhibition, mitotic index, cell viability, chromosome aberrations and cell survival have been taken into account. The data indicate that the antimitotic agent cis-HAD is active only at doses causing high cell mortality and chromosome damage. © 1981.
Antimitotic and cytotoxic activity of cis-dichlorobis-(cyclohexylamine)platinum(II) on Chinese hamster ovary cells
CELOTTI, LUCIA;
1981
Abstract
The antimitotic and cytotoxic effects of cis-dichlorobis(cyclohexylamine)platinum(II) (cis-HAD) which among Pt complexes used as antitumoral drugs shows the highest therapeutic index (TI) have been compared to those of cis-dichlorodiamine platinum(II) (cis-DDP), the most commonly used drug of this group, using Chinese hamster ovary cell cultures (CHO line). DNA synthesis inhibition, mitotic index, cell viability, chromosome aberrations and cell survival have been taken into account. The data indicate that the antimitotic agent cis-HAD is active only at doses causing high cell mortality and chromosome damage. © 1981.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
