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EnglishThe interactions between 2 angular pyranocoumarins and DNA have been studied in both ground and excited states. The compounds are able to intercalate inside DNA in a non-covalent manner and, under UV-A irradiation, to photobind covalently, forming pyran-side monoadducts and cross-links. The crystal structure of 4,6-dimethylpyranocoumarin was determined by X-ray diffraction techniques, and molecular arrangements in both ground and excited (singlet and triplet) states were calculated by the MNDO method. Results are discussed in terms of intercalation in the ground state, as shown by linear dichroism measurements, and covalent photobinding to pyrimidine bases of DNA under UV-A excitation.
| Titolo: | Pyranocoumarins as potential photochemotherapeutic agents: theoretical and physico-chemical studies on the mechanism of action |
| Autori: | |
| Data di pubblicazione: | 1991 |
| Rivista: | |
| Abstract: | The interactions between 2 angular pyranocoumarins and DNA have been studied in both ground and excited states. The compounds are able to intercalate inside DNA in a non-covalent manner and, under UV-A irradiation, to photobind covalently, forming pyran-side monoadducts and cross-links. The crystal structure of 4,6-dimethylpyranocoumarin was determined by X-ray diffraction techniques, and molecular arrangements in both ground and excited (singlet and triplet) states were calculated by the MNDO method. Results are discussed in terms of intercalation in the ground state, as shown by linear dichroism measurements, and covalent photobinding to pyrimidine bases of DNA under UV-A excitation. |
| Handle: | http://hdl.handle.net/11577/2512421 |
| Appare nelle tipologie: | 01.01 - Articolo in rivista |
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