Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells involved in endothelial repair and neo-angiogenesis. Quantitative and qualitative EPC alterations associate with classical cardiovascular risk factors as well as with established atherosclerotic diseases. Type 1 and type 2 diabetic patients show reduction and dysfunction of circulating EPCs, when compared to non diabetic subjects. In the presence of micro- and macrovascular diabetic complications, EPC levels are further reduced in parallel with disease severity. The causes of low EPCs in diabetes are not entirely clear, but defects in bone marrow mobilization processes appear to be predominantly involved. Low EPCs levels predict incident cardiovascular events in different cohorts of patients. Some pharmacological interventions are able to restore circulating EPCs levels, but it remains to be established whether or not this translates into cardiovascular protection
Endothelial progenitor cells in diabetes mellitus and its complications [Le cellule progenitrici endoteliali el diabete mellito sue complicanze]
FADINI, GIAN PAOLO;AVOGARO, ANGELO
2011
Abstract
Endothelial progenitor cells (EPCs) are bone marrow-derived stem cells involved in endothelial repair and neo-angiogenesis. Quantitative and qualitative EPC alterations associate with classical cardiovascular risk factors as well as with established atherosclerotic diseases. Type 1 and type 2 diabetic patients show reduction and dysfunction of circulating EPCs, when compared to non diabetic subjects. In the presence of micro- and macrovascular diabetic complications, EPC levels are further reduced in parallel with disease severity. The causes of low EPCs in diabetes are not entirely clear, but defects in bone marrow mobilization processes appear to be predominantly involved. Low EPCs levels predict incident cardiovascular events in different cohorts of patients. Some pharmacological interventions are able to restore circulating EPCs levels, but it remains to be established whether or not this translates into cardiovascular protectionPubblicazioni consigliate
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