We designed, synthesized and tested novel 2,6-disubstituted-anthraquinones able to bind dynamic secondary structures of nucleic acids, such as TAR RNA and its reverse transcript cTAR, leading to inhibition of the chaperone activities of the nucleocapsid NCp7, a highly conserved viral protein implied in crucial steps of HIV-1 replication.
Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-1 nucleocapsid inhibitors
SOSIC, ALICE;ZAGOTTO, GIUSEPPE;PAROLIN, MARIA CRISTINA;GATTO, BARBARA
2013
Abstract
We designed, synthesized and tested novel 2,6-disubstituted-anthraquinones able to bind dynamic secondary structures of nucleic acids, such as TAR RNA and its reverse transcript cTAR, leading to inhibition of the chaperone activities of the nucleocapsid NCp7, a highly conserved viral protein implied in crucial steps of HIV-1 replication.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
sosicetal2013MCC.pdf
Accesso riservato
Tipologia:
Published (Publisher's Version of Record)
Licenza:
Accesso privato - non pubblico
Dimensione
190.29 kB
Formato
Adobe PDF
|
190.29 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
