LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features of the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated the role of LKB1 as potential predictive marker of sensitivity to bevacizumab in advanced non-small cell lung cancer (aNSCLC).

LKB1 expression correlates with increased survival in advanced non-small cell lung cancer patients treated with chemotherapy and bevacizumab

Bonanno, Laura;De Paoli, Angela;Zulato, Elisabetta;CALABRESE, FIORELLA;Favaretto, Adolfo;Santo, Antonio;CICCARESE, FRANCESCO;Bertorelle, Roberta;De Salvo, Gian Luca;AMADORI, ALBERTO;Conte, Pierfranco;Indraccolo, Stefano
2017

Abstract

LKB1 is a key sensor of metabolic stress, including hypoxia and glucose deprivation, two features of the tumor microenvironment exacerbated by antiangiogenic therapy. We investigated the role of LKB1 as potential predictive marker of sensitivity to bevacizumab in advanced non-small cell lung cancer (aNSCLC).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3219763
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