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EnglishToll-like receptor 4 (TLR4) plays a key role in the induction of inflammatory responses both in peripheral organs and the CNS. Curcumin exerts anti-inflammatory functions by interfering with LPS-induced TLR4-myeloid differentiation protein-2 (MD-2) dimerization and suppressing pro-inflammatory mediator release. However, the inhibitory mechanism of curcumin remains to be defined.
| Titolo: | Phenolic 1,3-diketones attenuate lipopolysaccharide-induced inflammatory response by an alternative magnesium-mediated mechanism |
| Autori: | |
| Data di pubblicazione: | 2017 |
| Rivista: | |
| Abstract: | Toll-like receptor 4 (TLR4) plays a key role in the induction of inflammatory responses both in peripheral organs and the CNS. Curcumin exerts anti-inflammatory functions by interfering with LPS-induced TLR4-myeloid differentiation protein-2 (MD-2) dimerization and suppressing pro-inflammatory mediator release. However, the inhibitory mechanism of curcumin remains to be defined. |
| Handle: | http://hdl.handle.net/11577/3220117 |
| Appare nelle tipologie: | 01.01 - Articolo in rivista |
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