Several mutations in the gene coding for DJ-1 have been associated with early onset forms of parkinsonism. In spite of the massive effort spent by the scientific community in understanding the physiological role of DJ-1, a consensus on what DJ-1 actually does within the cells has not been reached, with several diverse functions proposed. At present, the most accepted function for DJ-1 is a neuronal protective role against oxidative stress. However, how exactly this function is exerted by DJ-1 is not clear. In recent years, novel molecular mechanisms have been suggested that may account for the antioxidant properties of DJ-1. In this review, we critically analyse the experimental evidence, including some very recent findings, supporting the purported neuroprotective role of DJ-1 through different mechanismslinked to oxidative stress handling, aswell as the relevance of these processes in the context of Parkinson's disease.

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.

BIOSA, ALICE
Writing – Original Draft Preparation
;
SANDRELLI, FEDERICA
Writing – Original Draft Preparation
;
BELTRAMINI, MARIANO
Writing – Review & Editing
;
GREGGIO, ELISA
Writing – Review & Editing
;
BUBACCO, LUIGI
Writing – Review & Editing
;
BISAGLIA, MARCO
Supervision
2017

Abstract

Several mutations in the gene coding for DJ-1 have been associated with early onset forms of parkinsonism. In spite of the massive effort spent by the scientific community in understanding the physiological role of DJ-1, a consensus on what DJ-1 actually does within the cells has not been reached, with several diverse functions proposed. At present, the most accepted function for DJ-1 is a neuronal protective role against oxidative stress. However, how exactly this function is exerted by DJ-1 is not clear. In recent years, novel molecular mechanisms have been suggested that may account for the antioxidant properties of DJ-1. In this review, we critically analyse the experimental evidence, including some very recent findings, supporting the purported neuroprotective role of DJ-1 through different mechanismslinked to oxidative stress handling, aswell as the relevance of these processes in the context of Parkinson's disease.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3242909
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