GREGGIO, ELISA
GREGGIO, ELISA
Dipartimento di Biologia - DiBio
Tyrosinase exacerbates dopamine and α-synuclein toxicity but is not genetically associated with Parkinson's disease
2005 Greggio, Elisa; Bergantino, Elisabetta; Carter, D.; Ahma, R.; Costin, G.; Hearing, V.; Clarimon, J.; Singleton, A.; Eerola, J.; Hellstrm, O.; Tienari, P.; Miller, D.; Beilina, A.; Bubacco, Luigi; Cookson, M.
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
2006 Momeni, P; Schymick, J; Jain, S; Cookson, Mr; Cairns, Nj; Greggio, E; Greenway, Mj; Berger, S; Pickering Brown, S; Chiò, A; Fung, Hc; Holtzman, Dm; Huey, Ed; Wassermann, Em; Adamson, J; Hutton, Ml; Rogaeva, E; St George Hyslop, P; Rothstein, Jd; Hardiman, O; Grafman, J; Singleton, A; Hardy, J; Traynor, Bj
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
2006 Greggio, E; Jain, S; Kingsbury, A; Bandopadhyay, R; Lewis, P; Kaganovich, A; van der Brug, Mp; Beilina, A; Blackinton, J; Thomas, Kj; Ahmad, R; Miller, Dw; Kesavapany, S; Singleton, A; Lees, A; Harvey, Rj; Harvey, K; Cookson, Mr
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
2007 Greggio, E; Lewis, Pa; van der Brug, Mp; Ahmad, R; Kaganovich, A; Ding, J; Beilina, A; Baker, Ak; Cookson, Mr
The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
2007 Lewis, Pa; Greggio, E; Beilina, A; Jain, S; Baker, A; Cookson, Mr
Kinase signaling pathways as potential targets in the treatment of Parkinson's disease.
2007 Greggio, E; Singleton, A.
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
2008 Greggio, E; Zambrano, I; Kaganovich, A; Beilina, A; Taymans, Jm; Daniëls, V; Lewis, P; Jain, S; Ding, J; Syed, A; Thomas, Kj; Baekelandt, V; Cookson, Mr
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
2008 Deng, J; Lewis, Pa; Greggio, E; Sluch, E; Beilina, A; Cookson, Mr
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
2008 Wang, L; Xie, C; Greggio, E; Parisiadou, L; Shim, H; Sun, L; Chandran, J; Lin, X; Lai, C; Yang, Wj; Moore, Dj; Dawson, Tm; Dawson, Vl; Chiosis, G; Cookson, Mr; Cai, H.
Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.
2009 Blackinton, J; Lakshminarasimhan, M; Thomas, Kj; Ahmad, R; Greggio, E; Raza, As; Cookson, Mr; Wilson, Ma
The R1441C mutation alters the folding properties of the ROC domain of LRRK2.
2009 Li, Y; Dunn, L; Greggio, E; Krumm, B; Jackson, Gs; Cookson, Mr; Lewis, Pa; Deng, J.
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.
2009 Greggio, E; Cookson, Mr
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
2009 Greggio, Elisa; Taymans, Jm; Zhen, Ey; Ryder, J; Vancraenenbroeck, R; Beilina, A; Sun, P; Deng, J; Jaffe, H; Baekelandt, V; Merchant, K; Cookson, Mr
alpha-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells
2010 Bisaglia, Marco; Greggio, Elisa; Maric, D; Miller, Dw; Cookson, Mr; Bubacco, Luigi
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
2010 Hsu, Ch; Chan, D; Greggio, E; Saha, S; Guillily, Md; Ferree, A; Raghavan, K; Shen, Gc; Segal, L; Ryu, H; Cookson, Mr; Wolozin, B.
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.
2010 Kumar, A; Greggio, E; Beilina, A; Kaganovich, A; Chan, D; Taymans, Jm; Wolozin, B; Cookson, Mr
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
2011 Daniëls, V; Vancraenenbroeck, R; Law, Bm; Greggio, Elisa; Lobbestael, E; Gao, F; De Maeyer, M; Cookson, Mr; Harvey, K; Baekelandt, V; Taymans, Jm
Structural and morphological characterization of aggregated species of {alpha}-synuclein induced by docosahexaenoic acid.
2011 DE FRANCESCHI, Giorgia; Frare, Erica; Pivato, Micaela; Relini, A; Penco, A; Greggio, Elisa; Bubacco, Luigi; Fontana, Angelo; POLVERINO DE LAURETO, Patrizia
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
2011 Greggio, Elisa; Bisaglia, Marco; Civiero, Laura; Bubacco, Luigi
Docosahexaenoic acid promotes and stabilizes oligomeric species of alpha-synuclein
2011 DE FRANCESCHI, Giorgia; Frare, Erica; Pivato, Micaela; Greggio, Elisa; A., Penco; A., Relini; Bubacco, Luigi; POLVERINO DE LAURETO, Patrizia