Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.
The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo
Menegazzo, Lisa;Scattolini, Valentina;Cappellari, Roberta;Bonora, Benedetta Maria;Albiero, Mattia;Bortolozzi, Mario;Romanato, Filippo;Ceolotto, Giulio;Avogaro, Angelo;Fadini, Gian Paolo
2018
Abstract
Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.
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