DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large-cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested that LCNEC are composed of two subtypes, one of which shares molecular anomalies with small-cell lung cancer. The missing piece of information is the transcriptomic relationship between AC and LCNEC, as a direct comparison is lacking in literature.
Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations
Fassan, Matteo;Pelosi, Giuseppe;Tortora, Giampaolo;Scarpa, Aldo;Bria, Emilio
2019
Abstract
DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large-cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested that LCNEC are composed of two subtypes, one of which shares molecular anomalies with small-cell lung cancer. The missing piece of information is the transcriptomic relationship between AC and LCNEC, as a direct comparison is lacking in literature.File in questo prodotto:
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