Rationale: Milk proteins have recognised functional properties on insulin and incretin secretion. In head-to-head comparisons, whey proteins (WP) are more efficient than casein (Cas) in hormone stimulation. Nevertheless, milk is a unique milieu, where interaction among proteins may modify their functional effects, and should not be excluded when comparing WP and Cas. Methods: We compared the effects, in young healthy volunteers, of milk loads under isolactose (3.6 g lactose x kg-1 BW) and isoproteic (0.18 g total protein x kg-1 BW) conditions. One was natural cow milk (Nat-Cow), with a Cas/WP ratio of 90/10, the other was a modified cow milk, obtained by water dilution and protein addition, to attain a WP/Cas ratio of 70/30 (High-WP milk). Blood ample were frequently taken over 4 hrs. Results: The same mild hyperglycemic response was observed. The HighWP milk exhibited a total AUC (þ z25%) and a [20’-120’] AUC (þ z45%) significantly greater (p<0.05) than those of Nat-Cow. The C-peptide response with the High-WP milk at 90’, and as the [20’-120’] AUC were greater (by þ60-80%) (p<0.05) than those of Nat-Cow milk. The [10’-90’] responses of both GLP-1 and GIP were 80-100% greater (p<0.05) with the High-WP than the Nat-Cow milk. Conclusion: Under under isolactose and isoproteic conditions, the reversal of the WP to Cas ratio in cow milk enhances insulin secretion in humans, possibly through an increased incretin response

Effect of Reversal of the Whey protein to casein ratio of cow milk on insulin and incretin responses in humans

P. Tessari
;
A. Lante;A. Toffolon;M. Vettore;E. Iori
2020

Abstract

Rationale: Milk proteins have recognised functional properties on insulin and incretin secretion. In head-to-head comparisons, whey proteins (WP) are more efficient than casein (Cas) in hormone stimulation. Nevertheless, milk is a unique milieu, where interaction among proteins may modify their functional effects, and should not be excluded when comparing WP and Cas. Methods: We compared the effects, in young healthy volunteers, of milk loads under isolactose (3.6 g lactose x kg-1 BW) and isoproteic (0.18 g total protein x kg-1 BW) conditions. One was natural cow milk (Nat-Cow), with a Cas/WP ratio of 90/10, the other was a modified cow milk, obtained by water dilution and protein addition, to attain a WP/Cas ratio of 70/30 (High-WP milk). Blood ample were frequently taken over 4 hrs. Results: The same mild hyperglycemic response was observed. The HighWP milk exhibited a total AUC (þ z25%) and a [20’-120’] AUC (þ z45%) significantly greater (p<0.05) than those of Nat-Cow. The C-peptide response with the High-WP milk at 90’, and as the [20’-120’] AUC were greater (by þ60-80%) (p<0.05) than those of Nat-Cow milk. The [10’-90’] responses of both GLP-1 and GIP were 80-100% greater (p<0.05) with the High-WP than the Nat-Cow milk. Conclusion: Under under isolactose and isoproteic conditions, the reversal of the WP to Cas ratio in cow milk enhances insulin secretion in humans, possibly through an increased incretin response
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3366286
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