Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investigated. The objective of this study was to examine proactive and reactive control functions in patients with focal brain tumors and to identify lesioned brain areas more at “risk” for developing impairment of these functions. To this end, a group of twenty-two patients, candidate to surgery, were tested with an AX-CPT task and a Stroop task, along with a clinical neuropsychological assessment, and their performance was compared to that of a well-matched healthy control group. Although overall accuracy and response times were similar for patients and control groups, the patient group failed more on the BX trials of the AX-CPT task and the incongruent trials of the Stroop task, specifically. Behavioral results were associated with the damaged brain areas, more centered in right frontal regions, by means of a lesion-symptom mapping multivariate approach. This analysis showed that a white matter cluster in the right prefrontal area was associated with lower d’-context values on the AX-CPT, which reflect the fact that these patients rely more on later information (reactive processes) to respond to unexpected and conflicting stimuli, than on earlier contextual cues (proactive processes). Taken together, these results suggest that patients with brain tumors present an unbalance between proactive and reactive control strategies in more interfering conditions, in association with right prefrontal white matter lesions.

Impaired cognitive control in patients with brain tumors

Vincenza Tarantino;Antonino Visalli;Silvia Facchini;Chiara Rossato;Alessandra Bertoldo;Erica Silvestri;Diego Cecchin;Mariagrazia Capizzi;Mariagiulia Anglani;Valentina Baro;Luca Denaro;Domenico D’Avella;Maurizio Corbetta;Antonino Vallesi
Supervision
2022

Abstract

Though the assessment of cognitive functions is proven to be a reliable prognostic indicator in patients with brain tumors, some of these functions, such as cognitive control, are still rarely investigated. The objective of this study was to examine proactive and reactive control functions in patients with focal brain tumors and to identify lesioned brain areas more at “risk” for developing impairment of these functions. To this end, a group of twenty-two patients, candidate to surgery, were tested with an AX-CPT task and a Stroop task, along with a clinical neuropsychological assessment, and their performance was compared to that of a well-matched healthy control group. Although overall accuracy and response times were similar for patients and control groups, the patient group failed more on the BX trials of the AX-CPT task and the incongruent trials of the Stroop task, specifically. Behavioral results were associated with the damaged brain areas, more centered in right frontal regions, by means of a lesion-symptom mapping multivariate approach. This analysis showed that a white matter cluster in the right prefrontal area was associated with lower d’-context values on the AX-CPT, which reflect the fact that these patients rely more on later information (reactive processes) to respond to unexpected and conflicting stimuli, than on earlier contextual cues (proactive processes). Taken together, these results suggest that patients with brain tumors present an unbalance between proactive and reactive control strategies in more interfering conditions, in association with right prefrontal white matter lesions.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11577/3417357
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