The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (<= 32 weeks gestation and/or birthweight <= 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV=SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29-31]; birthweight 1300 g [950-1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p= 0.010 and 0.030), and nappy change (p < 0.001 and <0.001), in the absence of a difference during parental presence.Conclusions: Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose.

Glucose variability increases during minimally invasive procedures in very preterm infants

Galderisi, Alfonso
;
Res, Giulia;Guiducci, Silvia;Savio, Federica;Brigadoi, Sabrina;Forlani, Laura;Moschino, Laura;Priante, Elena;Trevisanuto, Daniele;Baraldi, Eugenio
2022

Abstract

The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (<= 32 weeks gestation and/or birthweight <= 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV=SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29-31]; birthweight 1300 g [950-1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p= 0.010 and 0.030), and nappy change (p < 0.001 and <0.001), in the absence of a difference during parental presence.Conclusions: Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3462841
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