This mini-review provides an overview of approaches to19F-labeling of nucleic acids. A special attention is paid to applications of19F-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.
Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy
Rigo R.
2022
Abstract
This mini-review provides an overview of approaches to19F-labeling of nucleic acids. A special attention is paid to applications of19F-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.
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