BERTAGNIN, CHIARA
BERTAGNIN, CHIARA
Dipartimento di Medicina Molecolare - DMM
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors
2021 Pismataro, M. C.; Felicetti, T.; Bertagnin, C.; Nizi, M. G.; Bonomini, A.; Barreca, M. L.; Cecchetti, V.; Jochmans, D.; De Jonghe, S.; Neyts, J.; Loregian, A.; Tabarrini, O.; Massari, S.
A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation
2023 Zhang, J.; Liu, C.; Jia, R.; Zhang, X.; Zhang, J.; Bertagnin, C.; Bonomini, A.; Guizzo, L.; Jiang, Y.; Jia, H.; Jia, S.; Ma, X.; Loregian, A.; Huang, B.; Zhan, P.; Liu, X.
A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth
2020 Celegato, M.; Messa, L.; Goracci, L.; Mercorelli, B.; Bertagnin, C.; Spyrakis, F.; Suarez, I.; Cousido-Siah, A.; Trave, G.; Banks, L.; Cruciani, G.; Palu, G.; Loregian, A.
A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells
2018 Messa, Lorenzo; Celegato, Marta; Bertagnin, Chiara; Mercorelli, Beatrice; Nannetti, Giulio; Palù, Giorgio; Loregian, Arianna
A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells
2023 Bertagnin, C.; Messa, L.; Pavan, M.; Celegato, M.; Sturlese, M.; Mercorelli, B.; Moro, S.; Loregian, A.
Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity
2021 Jia, R.; Zhang, J.; Bertagnin, C.; Cherukupalli, S.; Ai, W.; Ding, X.; Li, Z.; Zhang, J.; Ju, H.; Ma, X.; Loregian, A.; Huang, B.; Zhan, P.; Liu, X.
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties
2023 Jia, R.; Zhang, J.; Shi, F.; Bonomini, A.; Lucca, C.; Bertagnin, C.; Zhang, J.; Liu, C.; Jia, H.; Jiang, Y.; Ma, X.; Loregian, A.; Huang, B.; Zhan, P.; Liu, X.
Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant
2022 Jia, Ruifang; Zhang, Jiwei; Zhang, Jian; Bertagnin, Chiara; Bonomini, Anna; Guizzo, Laura; Gao, Zhen; Ji, Xiangkai; Li, Zhuo; Liu, Chuanfeng; Ju, Han; Ma, Xiuli; Loregian, Arianna; Huang, Bing; Zhan, Peng; Liu, Xinyong
Elaborate Structural Modifications Yielding Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Potent Neuraminidase Inhibitors with Significantly Improved Broad-Spectrum Antiresistance Profiles
2024 Zhang, Jiwei; Jia, Ruifang; Jia, Huinan; Li, Ping; Jiang, Yuanmin; Bonomini, Anna; Bertagnin, Chiara; Xu, Qiaojie; Tan, Zhou; Ma, Xiuli; Loregian, Arianna; Huang, Bing; Liu, Xinyong; Zhan, Peng
Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA–PB1 Subunits Interaction
2024 Giacchello, I.; Cianciusi, A.; Bertagnin, C.; Bonomini, A.; Francesconi, V.; Mori, M.; Carbone, A.; Musumeci, F.; Loregian, A.; Schenone, S.
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability
2021 Ju, H.; Murugan, N. A.; Hou, L.; Li, P.; Guizzo, L.; Zhang, Y.; Bertagnin, C.; Kong, X.; Kang, D.; Jia, R.; Ma, X.; Du, R.; Poongavanam, V.; Loregian, A.; Huang, B.; Liu, X.; Zhan, P.
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity
2022 Ju, Han; Hou, Lingxin; Zhao, Fabao; Zhang, Ying; Jia, Ruifang; Guizzo, Laura; Bonomini, Anna; Zhang, Jiwei; Gao, Zhen; Liang, Ruipeng; Bertagnin, Chiara; Kong, Xiujie; Ma, Xiuli; Kang, Dongwei; Loregian, Arianna; Huang, Bing; Liu, Xinyong; Zhan, Peng
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant
2018 Zhang, Jian; Poongavanam, Vasanthanathan; Kang, Dongwei; Bertagnin, Chiara; Lu, Huamei; Kong, Xiujie; Ju, Han; Lu, Xueyi; Gao, Ping; Tian, Ye; Jia, Haiyong; Desta, Samuel; Ding, Xiao; Sun, Lin; Fang, Zengjun; Huang, Boshi; Liang, Xuewu; Jia, Ruifang; Ma, Xiuli; Xu, Wenfang; Murugan, Natarajan Arul; Loregian, Arianna; Huang, Bing; Zhan, Peng; Liu, Xinyong
Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization
2024 Bonomini, A.; Felicetti, T.; Pacetti, M.; Bertagnin, C.; Coletti, A.; Giammarino, F.; De Angelis, M.; Poggialini, F.; Macchiarulo, A.; Sabatini, S.; Mercorelli, B.; Nencioni, L.; Vicenti, I.; Dreassi, E.; Cecchetti, V.; Tabarrini, O.; Loregian, A.; Massari, S.
Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance
2019 Nannetti, Giulio; Massari, Serena; Mercorelli, Beatrice; Bertagnin, Chiara; Desantis, Jenny; Palù, Giorgio; Tabarrini, Oriana; Loregian, Arianna
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant
2018 Zhang, Jian; Murugan, Natarajan Arul; Tian, Ye; Bertagnin, Chiara; Fang, Zengjun; Kang, Dongwei; Kong, Xiujie; Jia, Haiyong; Sun, Zhuosen; Jia, Ruifang; Gao, Ping; Poongavanam, Vasanthanathan; Loregian, Arianna; Xu, Wenfang; Ma, Xiuli; Ding, Xiao; Huang, Bing; Zhan, Peng; Liu, Xinyong
Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines
2024 Pacetti, Martina; Pismataro, Maria Chiara; Felicetti, Tommaso; Giammarino, Federica; Bonomini, Anna; Tiecco, Matteo; Bertagnin, Chiara; Barreca, Maria Letizia; Germani, Raimondo; Cecchetti, Violetta; Vicenti, Ilaria; Tabarrini, Oriana; Zazzi, Maurizio; Loregian, Arianna; Massari, Serena
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
2021 Massari, S.; Bertagnin, C.; Pismataro, M. C.; Donnadio, A.; Nannetti, G.; Felicetti, T.; Di Bona, S.; Nizi, M. G.; Tensi, L.; Manfroni, G.; Loza, M. I.; Sabatini, S.; Cecchetti, V.; Brea, J.; Goracci, L.; Loregian, A.; Tabarrini, O.
Targeted disruption of e6/p53 binding exerts broad activity and synergism with paclitaxel and topotecan against hpv-transformed cancer cells
2022 Celegato, M.; Messa, L.; Bertagnin, C.; Mercorelli, B.; Loregian, A.
The dimeric form of hpv16 e6 is crucial to drive yap/taz upregulation through the targeting of hscrib
2021 Messa, L.; Celegato, M.; Bertagnin, C.; Mercorelli, B.; Alvisi, G.; Banks, L.; Palu, G.; Loregian, A.