Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear. This lack of understanding is partly due to the cellular models used to explore this phenomenon (cell lines or pooled islets), which are non-physiologic and have limited clinical transferability.

Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures

SCATTOLINI, VALENTINA;LUNI, CAMILLA;ZAMBON, ALESSANDRO;GALVANIN, SILVIA;GAGLIANO, ONELIA;CIUBOTARU, CATALIN DACIAN;AVOGARO, ANGELO;MAMMANO, FABIO;ELVASSORE, NICOLA;FADINI, GIAN PAOLO
2016

Abstract

Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear. This lack of understanding is partly due to the cellular models used to explore this phenomenon (cell lines or pooled islets), which are non-physiologic and have limited clinical transferability.
2016
File in questo prodotto:
File Dimensione Formato  
art%253A10.1007%252Fs13300-016-0210-y.pdf

accesso aperto

Descrizione: PDF
Tipologia: Preprint (submitted version)
Licenza: Accesso gratuito
Dimensione 4.65 MB
Formato Adobe PDF
4.65 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11577/3208420
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 10
social impact