A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling and metabolic signatures, as surrogates for cardiovascular risk, in hypertensive patients.
High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension.
Rossitto, Giacomo
;Maiolino, Giuseppe;Lerco, Silvia;Ceolotto, Giulio;Antonelli, Giorgia;Bisogni, Valeria;Cesari, Maurizio;Seccia, Teresa Maria;Lenzini, Livia;Pinato, Alessio;Plebani, Mario;Rossi, Gian Paolo;
2021
Abstract
A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling and metabolic signatures, as surrogates for cardiovascular risk, in hypertensive patients.
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