Sfoglia per Autore
DA7R: A 7-Letter Zip Code to Target PDAC
2023 Parrasia, Sofia; Rossa, Andrea; Roncaglia, Nicola; Mattarei, Andrea; Honisch, Claudia; Szabò, Ildikò; Ruzza, Paolo; Biasutto, Lucia
Drug–Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism
2023 Ferri, N.; De Martin, S.; Stuart, J.; Traversa, S.; Folli, F.; Pappagallo, M.; O’Gorman, C.; Guidetti, C.; Mattarei, A.; Inturrisi, C. E.; Manfredi, P. L.
Subanalysis of Subjective Cognitive Measures From a Phase 2, Double-Blind, Randomized Trial of REL-1017 in Patients With Major Depressive Disorder
2023 Guidetti, Clotilde; Serra, Giulia; Pani, Luca; Pappagallo, Marco; Maglio, Gino; Martin, Sara De; Mattarei, Andrea; Folli, Franco; Manfredi, Paolo L; Fava, Maurizio
Efficient SARS-CoV-2 infection antagonization by rhACE2 ectodomain multimerized onto the Avidin-Nucleic-Acid-NanoASsembly
2023 Bernardotto, Simone; Frasson, Ilaria; Faravelli, Silvia; Morelli, Annalisa; Schiavon, Elisa; Moscatiello, Giulia Yuri; Violatto, Martina Bruna; Pinnola, Alberta; Canciani, Anselmo; Mattarei, Andrea; Rossi, Gianpaolo; Brini, Marisa; Pasetto, Laura; Bonetto, Valentina; Bigini, Paolo; Forneris, Federico; Richter, Sara N.; Morpurgo, Margherita
Esmethadone-HCl (REL-1017): a promising rapid antidepressant
2023 Fava, Maurizio; Stahl, Stephen M; De Martin, Sara; Mattarei, Andrea; Bettini, Ezio; Comai, Stefano; Alimonti, Andrea; Bifari, Francesco; Pani, Luca; Folli, Franco; Guidetti, Clotilde; Furlan, Alberto; Sgrignani, Jacopo; Locatelli, Patrizia; Cavalli, Andrea; O'Gorman, Cedric; Traversa, Sergio; Inturrisi, Charles E; Pappagallo, Marco; Manfredi, Paolo L
The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users
2023 Shram, Megan J; Henningfield, Jack E; Apseloff, Glen; Gorodetzky, Charles W; De Martin, Sara; Vocci, Frank L; Sapienza, Frank L; Kosten, Thomas R; Huston, Jeff; Buchhalter, August; Ashworth, Judy; Lanier, Ryan; Folli, Franco; Mattarei, Andrea; Guidetti, Clotilde; Comai, Stefano; O'Gorman, Cedric; Traversa, Sergio; Inturrisi, Charles E; Manfredi, Paolo L; Pappagallo, Marco
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle
2023 Marchioretti, Caterina; Zanetti, Giulia; Pirazzini, Marco; Gherardi, Gaia; Nogara, Leonardo; Andreotti, Roberta; Martini, Paolo; Marcucci, Lorenzo; Canato, Marta; R Nath, Samir; Zuccaro, Emanuela; Chivet, Mathilde; Mammucari, Cristina; Pacifici, Marco; Raffaello, Anna; Rizzuto, Rosario; Mattarei, Andrea; Desbats, MARIA ANDREA; Salviati, Leonardo; Megighian, Aram; Sorarù, Gianni; Pegoraro, Elena; Belluzzi, Elisa; Pozzuoli, Assunta; Biz, Carlo; Ruggieri, Pietro; Romualdi, Chiara; P Lieberman, Andrew; J Babu, Gopal; Sandri, Marco; Blaauw, Bert; Basso, Manuela; Pennuto, Maria
Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors
2022 Bettini, Ezio; Stahl, Stephen M; De Martin, Sara; Mattarei, Andrea; Sgrignani, Jacopo; Carignani, Corrado; Nola, Selena; Locatelli, Patrizia; Pappagallo, Marco; Inturrisi, Charles E; Bifari, Francesco; Cavalli, Andrea; Alimonti, Andrea; Pani, Luca; Fava, Maurizio; Traversa, Sergio; Folli, Franco; Manfredi, Paolo L
The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence
2022 Ongaro, A.; Violatto, M. B.; Casarin, E.; Pellerani, I.; Marchini, G.; Ribaudo, G.; Salmona, M.; Carbone, M.; Passoni, A.; Gnodi, E.; Schiavon, E.; Mattarei, A.; Barisani, D.; Invernizzi, P.; Bigini, P.; Morpurgo, M.
Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo
2022 Bachmann, Magdalena; Rossa, Andrea; Varanita, Tatiana; Fioretti, Bernard; Biasutto, Lucia; Milenkovic, Stefan; Checchetto, Vanessa; Peruzzo, Roberta; Ahmad, Syed A; Patel, Sameer H; Lukowski, Robert; Edwards, Michael J; Ceccarelli, Matteo; Gulbins, Erich; Zoratti, Mario; Mattarei, Andrea; Szabo, Ildiko
Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model
2022 Severin, F.; Urbani, A.; Varanita, T.; Bachmann, M.; Azzolini, M.; Martini, V.; Pizzi, M.; Dei Tos, A. P.; Frezzato, F.; Mattarei, A.; Ghia, P.; Bertilaccio, M. T. S.; Gulbins, E.; Paradisi, C.; Zoratti, M.; Semenzato, G. C.; Leanza, L.; Trentin, L.; Szabo, I.
REL-1017 (Esmethadone) May Rapidly Reduce Dissociative Symptoms in Adults With Major Depressive Disorder Unresponsive to Standard Antidepressants: A Report of 2 Cases
2022 Guidetti, Clotilde; Serra, Giulia; Pani, Luca; Pappagallo, Marco; Maglio, Gino; Trasolini, Monia; De Martin, Sara; Mattarei, Andrea; Bifari, Francesco; Folli, Franco; Manfredi, Paolo L; Fava, Maurizio
The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin
2022 Bettini, Ezio; De Martin, Sara; Mattarei, Andrea; Pappagallo, Marco; Stahl, Stephen M; Bifari, Francesco; Inturrisi, Charles E; Folli, Franco; Traversa, Sergio; Manfredi, Paolo L
Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine Model
2022 Li, Weiwei; Wilson, Gregory C; Bachmann, Magdalena; Wang, Jiang; Mattarei, Andrea; Paradisi, Cristina; Edwards, Michael J; Szabo, Ildiko; Gulbins, Erich; Ahmad, Syed A; Patel, Sameer H
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial
2022 Fava, M.; Stahl, S.; Pani, L.; De Martin, S.; Pappagallo, M.; Guidetti, C.; Alimonti, A.; Bettini, E.; Mangano, R. M.; Wessel, T.; de Somer, M.; Caron, J.; Vitolo, O. V.; Diguglielmo, G. R.; Gilbert, A.; Mehta, H.; Kearney, M.; Mattarei, A.; Gentilucci, M.; Folli, F.; Traversa, S.; Inturrisi, C. E.; Manfredi, P. L.
Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma
2022 Kadow, Stephanie; Schumacher, Fabian; Kramer, Melanie; Hessler, Gabriele; Scholtysik, René; Oubari, Sara; Johansson, Patricia; Hüttmann, Andreas; Reinhardt, Hans Christian; Kleuser, Burkhard; Zoratti, Mario; Mattarei, Andrea; Szabò, Ildiko; Gulbins, Erich; Carpinteiro, Alexander
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling
2022 Stahl, Stephen M; De Martin, Sara; Mattarei, Andrea; Bettini, Ezio; Pani, Luca; Guidetti, Clotilde; Folli, Franco; de Somer, Marc; Traversa, Sergio; Inturrisi, Charles E; Pappagallo, Marco; Gentilucci, Marco; Alimonti, Andrea; Fava, Maurizio; Manfredi, Paolo L
An Agonist of the CXCR4 Receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming
2022 Stazi, Marco; Fabris, Federico; Yi Tan, Kae; Megighian, Aram; Rubini, Alessandro; Mattarei, Andrea; Negro, Samuele; D'Este, Giorgia; Lista, Florigio; Rossetto, Ornella; Hock Tan, Choo; Montecucco, Cesare
An angiopep2-paptp construct overcomes the blood-brain barrier. New perspectives against brain tumors
2021 Parrasia, S.; Rossa, A.; Varanita, T.; Checchetto, V.; De Lorenzi, R.; Zoratti, M.; Paradisi, C.; Ruzza, P.; Mattarei, A.; Szabo, I.; Biasutto, L.
Synthesis and cellular effects of a mitochondria-targeted inhibitor of the two-pore potassium channel TASK-3
2021 Bachmann, M.; Rossa, A.; Antoniazzi, G.; Biasutto, L.; Carrer, A.; Campagnaro, M.; Leanza, L.; Gonczi, M.; Csernoch, L.; Paradisi, C.; Mattarei, A.; Zoratti, M.; Szabo, I.
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