SISSI, CLAUDIA
 Distribuzione geografica
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Continente #
NA - Nord America 8.701
EU - Europa 823
AS - Asia 393
OC - Oceania 3
SA - Sud America 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.924
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Nazione #
US - Stati Uniti d'America 8.694
CN - Cina 335
IT - Italia 195
DE - Germania 169
FI - Finlandia 165
GB - Regno Unito 92
UA - Ucraina 90
SE - Svezia 68
VN - Vietnam 21
JP - Giappone 17
CZ - Repubblica Ceca 12
IE - Irlanda 12
CA - Canada 7
NL - Olanda 6
IN - India 5
TW - Taiwan 4
FR - Francia 3
GR - Grecia 3
TR - Turchia 3
AE - Emirati Arabi Uniti 2
IL - Israele 2
NZ - Nuova Zelanda 2
PL - Polonia 2
RO - Romania 2
VE - Venezuela 2
AM - Armenia 1
AU - Australia 1
BD - Bangladesh 1
BG - Bulgaria 1
CL - Cile 1
ES - Italia 1
EU - Europa 1
PH - Filippine 1
PT - Portogallo 1
SI - Slovenia 1
UZ - Uzbekistan 1
Totale 9.924
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Città #
Fairfield 1.594
Woodbridge 1.234
Houston 711
Ann Arbor 675
Ashburn 594
Seattle 590
Cambridge 538
Wilmington 509
Jacksonville 461
Chandler 456
Princeton 211
San Diego 167
Roxbury 92
Beijing 75
Medford 74
Nanjing 73
Des Moines 58
Helsinki 56
Boardman 53
Padova 50
Nanchang 28
Hebei 22
London 22
Shenyang 22
Dong Ket 21
Los Angeles 21
Napoli 20
Jiaxing 18
Guangzhou 16
Norwalk 13
Tianjin 12
Changsha 11
New York 10
Dublin 9
Letovice 9
Milan 9
Tappahannock 9
Indiana 8
Jinan 8
Kilburn 8
Osaka 8
Teolo 8
Nürnberg 7
Ogden 7
Rome 7
Arre 6
Hounslow 6
Tokyo 6
Vicenza 6
Borås 5
Falls Church 5
Redwood City 5
Yellow Springs 5
Chiswick 4
Escanaba 4
Essen 4
Kharkiv 4
Kolkata 4
Ningbo 4
Taipei 4
Umeå 4
Venice 4
Washington 4
Zhengzhou 4
Costa Mesa 3
Dearborn 3
Ferrara 3
Haikou 3
Hefei 3
Jülich 3
Kozani 3
Kunming 3
New Bedfont 3
Phoenix 3
Prescot 3
San Francisco 3
Aachen 2
Agordo 2
Alghero 2
Amsterdam 2
Antalya 2
Boara 2
Bologna 2
Camerino 2
Chengdu 2
Chicago 2
Dubai 2
Formia 2
Fremont 2
Gröbenzell 2
Hadera 2
Hangzhou 2
Ottawa 2
Pellezzano 2
Pianiga 2
Pinehaven 2
Piove Di Sacco 2
Pula 2
Qingdao 2
Radomsko 2
Totale 8.776
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Nome #
Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst 128
Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models 121
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 120
DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action 114
Tuning G-quadruplex vs. double stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates 112
Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential 110
DNA-Interactive Anticancer Aza-Anthrapyrazoles: Biophysical and Biochemical Studies Relevant to the Mechanism of Action 110
Design and synthesis of modified quinolones as antitumoral acridones 109
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties 109
Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine- Based Polyamine Ligands in the Binding of Double Helix and G-Quadruplex DNA 108
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents 104
A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts 102
Folding versus charge: understanding selective target recognition by the thrombin aptamers 100
Biologically relevant Cu2+ complexes with a tridentate phenanthroline analogue: structural properties and DNA damage 100
DNA-binding preferences of bisantrene analogues: Relevance to the sequence specificity of drug-mediated topoisomerase II poisoning 99
Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy 99
G-quadruplexes in human promoters: A challenge for therapeutic applications 99
Ferulic Acid Esters and Withanolides: In Search of Withania somnifera GABAA Receptor Modulators 99
Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity 98
Molecular Basis for Differential Recognition of G-Quadruplex versus Double-Helix DNA by Bis-Phenanthroline Metal Complexes 98
Aminoacyl-analogues of Mitoxantrone as novel DNA-damaging cytotoxic agents 97
DNA phosphodiester bond hydrolysis mediated by Cu(II) and Zn(II) complexes of 1,3,5-triaminocyclohexane derivatives 97
Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions 97
The effects of metal ions on the structure and stability of the DNA gyrase B protein 96
In Silico Identification of Piperidinyl-amine Derivatives as Novel Dual Binders of Oncogene c-myc/c-Kit G-quadruplexes 95
pH-driven conformational switch between non-canonical DNA structures in a C-rich domain of EGFR promoter 95
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation 93
Tuning the activity of Zn(II) complexes in DNA cleavage: Clues for design of new efficient metallo-hydrolases 93
Phosphate diesters and DNA hydrolysis by dinuclear Zn(II) complexes featuring a disulfide bridge and H-bond donors 92
Distinct biological responses of metastatic castration resistant prostate cancer cells upon exposure to G-quadruplex interacting naphthalenediimide derivatives 92
Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures 91
G-rich sequences within proto-oncogene KIT promoter region as targets for anticancer therapy. 91
Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA 91
Telomeric G-quadruplex architecture and interactions with potential drugs 91
Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule 91
Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G 90
Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners 89
Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Agents 89
Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones 87
Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties 86
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains 86
Efficient Plasmid DNA Cleavage by a Mononuclear Copper(II) Complex 85
DNA targeting by cationic porphyrin-ruthenium(II) conjugates 85
Further insight into the Zn2+-mediated binding of streptonigrin to DNA 85
Interactions of selected gold(iii) complexes with DNA G quadruplexes 85
Two-quartet kit* G-quadruplex is formed via double-stranded pre-folded structure 85
Effects of Magnesium and related divalent metal ions in topoisomerase structure and function 83
Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease? 83
Modulation of Antithrombin-Protease Interactions by Semisynthetic Low-Molecular-Weight Heparins with Different Sulfation Patterns 83
Structure-activity relationships of novel substituted naphthalene diimides as anticancer agents 82
Impairment of c-kit expression in human cancer cell lines by a novel pharmacophoric unit selected for the recognition of the proto-oncogene KIT promotorial region. 82
Dinuclear Zn2+ complexes of synthetic heptapeptides as artificial nucleases 82
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. 81
Macrocyclic naphthalene diimides as G-quadruplex binders 81
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 81
Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting 80
Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites 80
Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action 80
Pt-based drugs: the spotlight will be on proteins 80
Peptidyl anthraquinones as potential antineoplastic drugs: synthesis, DNA-binding, redox cycling and biological activity 79
Bis-phenanthroline derivatives as suitable scaffolds for effective G-quadruplex recognition 78
Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity and physico-chemical properties of 2-aza and 2-aza-oxide-anthracenedione derivatives 77
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity 77
Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents 76
Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I 76
Targeting canine c-KIT promoter by a candidate DNA G-quadruplex ligand 75
Novel insights on the DNA interaction of calicheamicin γI1 75
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences 74
Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation 74
DNA binding by a new metallointercalator containing a proflavine group bearing a hanging chelating unit 73
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases 73
Mg2+-mediated binding of 6-substituted quinolones to DNA: Relevance to biological activity 73
G-Quadruplex Modulation of SP1 Functional Binding Sites at the KIT Proximal Promoter 73
Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition 72
Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches 72
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective 72
Characterization of G4-G4 Crosstalk in the c-KIT Promoter Region 72
DNA topoisomerase-targeted drugs 71
Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA. 71
Remarkable interference with telomeric function by a G-quadruplex-selective bisantrene regioisomer 70
Mapping simocyclinone D8 interaction to DNA gyrase: evidence for a new binding site on GyrB 70
Effective DNA inhibitors of Cathepsin G by in vitro selection 70
Preferred interaction of D-peptidyl-anthraquinones with double-stranded B-DNA 70
Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter 69
Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligands 68
Targeting canine kit promoter by candidate DNA G-quadruplex ligands 68
The quinolone family: from antibacterial to anticancer agents 68
Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions 67
Toward efficient Zn(II)-based artificial nucleases 67
Molecular recognition of human telomeric DNA by phenanthroline-based G-quadruplex ligands 66
Effects of Sulfation on Antithrombin-Thrombin/Factor Xa Interactions in Semisynthetic Low-Molecular Weight Heparins 65
Chromophore-modified antitumor anthracenediones: synthesis, DNA binding and cytotoxic activity of 1,4-bis[(aminoalkil)amino]benzo [g]phthalazine-5,10-diones 64
Conformational profiling of a G-rich sequence within the c-KIT promoter 64
Sequence selectivity of Topoisomerase II DNA cleavage stimulated by Mitoxantrone derivatives: relationships with drug DNA binding and cellular effects 63
A G-quadruplex binding compound down-regulates KIT, BCL2 and PDGFRβ expression in human gastric carcinoma cell line 62
DNA reactivity profile of trans-platinum planar amine derivatives 62
Inflammatory cytokine expression following the use of bipolar electrocoagulation, ultracision harmonic scalpel and cold knife biopsy 62
New peptidyl-anthraquinones: Synthesis and DNA binding 62
Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8-aza and 9-aza regioisomers 60
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage. 60
Totale 8.411
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Categoria #
all - tutte 34.580
article - articoli 32.976
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 394
Totale 67.950
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019761 0 0 0 0 0 0 0 0 0 0 419 342
2019/20202.273 330 84 28 194 261 189 221 286 245 238 84 113
2020/20211.438 51 146 32 161 48 96 62 158 227 172 197 88
2021/20222.030 65 273 342 106 72 106 117 221 77 48 244 359
2022/20231.059 258 92 14 120 164 114 5 68 132 14 59 19
2023/2024410 13 81 74 42 41 38 31 32 21 33 4 0
Totale 10.039