GATTO, BARBARA
 Distribuzione geografica
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Continente #
NA - Nord America 7.472
EU - Europa 1.758
AS - Asia 434
SA - Sud America 10
OC - Oceania 2
Totale 9.676
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Nazione #
US - Stati Uniti d'America 7.459
IT - Italia 1.117
CN - Cina 367
FI - Finlandia 154
UA - Ucraina 111
DE - Germania 110
SE - Svezia 84
GB - Regno Unito 82
FR - Francia 38
VN - Vietnam 20
CA - Canada 13
CH - Svizzera 12
IN - India 11
HK - Hong Kong 9
BE - Belgio 8
CZ - Repubblica Ceca 8
IE - Irlanda 7
CL - Cile 5
JP - Giappone 5
KR - Corea 5
NL - Olanda 5
PL - Polonia 5
BR - Brasile 4
ES - Italia 4
TR - Turchia 4
GR - Grecia 3
TW - Taiwan 3
AU - Australia 2
DK - Danimarca 2
IR - Iran 2
LU - Lussemburgo 2
MO - Macao, regione amministrativa speciale della Cina 2
SK - Slovacchia (Repubblica Slovacca) 2
AE - Emirati Arabi Uniti 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
IL - Israele 1
JO - Giordania 1
MY - Malesia 1
PK - Pakistan 1
RO - Romania 1
RU - Federazione Russa 1
SG - Singapore 1
Totale 9.676
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Città #
Fairfield 1.155
Woodbridge 929
Houston 736
Chandler 605
Ann Arbor 570
Jacksonville 524
Ashburn 483
Wilmington 425
Seattle 394
Cambridge 372
Princeton 193
Padova 123
San Diego 119
Beijing 98
Milan 82
Nanjing 76
Rome 64
Medford 63
Roxbury 61
Helsinki 52
Des Moines 47
Boardman 40
Guangzhou 32
Naples 26
Shenyang 26
Norwalk 25
Dong Ket 20
Genoa 19
Nanchang 19
Napoli 17
Hebei 16
London 15
Bologna 14
Hefei 11
Parma 11
Cagliari 10
Jiaxing 10
Trieste 10
Changsha 9
Tianjin 9
Toronto 9
Udine 9
Columbus 8
Jinan 8
Kilburn 8
Margherita Di Savoia 8
Pisa 8
Redwood City 8
Trento 8
Dublin 7
Florence 7
Indiana 7
Kowloon 7
Kraainem 7
Phoenix 7
Turin 7
Washington 7
Borås 6
Civitella Messer Raimondo 6
Ferrara 6
New York 6
Portadown 6
Salerno 6
Verona 6
Chicago 5
Falls Church 5
Hounslow 5
Matera 5
Munich 5
Nardò 5
Supino 5
Tappahannock 5
Torino 5
Vicenza 5
Zurich 5
Acerra 4
Camponogara 4
Cittadella 4
Gorizia 4
Kharkiv 4
Kunming 4
Longare 4
Los Angeles 4
Messina 4
Modena 4
Montebello Vicentino 4
Mugnano di Napoli 4
Paderno Dugnano 4
Paris 4
Pavia 4
Segrate 4
Toulouse 4
Venice 4
Agropoli 3
Bari 3
Battaglia Terme 3
Belfast 3
Belpasso 3
Capoterra 3
Carpi 3
Totale 7.830
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Nome #
Dall’evoluzione in vitro alle nanotecnologie: gli aptameri come biosensori 1.022
Cellular pharmacology of PNU-159682, a liver microsomal metabolite of methoxymorpholinyl doxorubicin (Nemorubicin; MMDX) 166
Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines as Potential Anticancer Agents 155
The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for the irreversible stimulation of DNA cleavage 139
Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein 130
Bis-3-chloropiperidines containing bridging lysine linkers: Influence of side chain structure on DNA alkylating activity 127
Development and Optimization of a Thrombin Sandwich Aptamer Microarray 123
Effects of common buffer systems on drug activity: the case of clerocidin 122
Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-Selective Peptidyl Congeners of Ametantrone 121
Synthesis and in Vitro Screening of New Series of 2,6-Dipeptidyl-anthraquinones: Influence of Side Chain Length on HIV-1 Nucleocapsid Inhibitors 120
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 120
Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar 117
6-aminoquinolones as new potential anti-HIV agents 117
Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors 116
Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action 115
The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein 112
DNA minor groove-binding ligands: A different class of mammalian DNA topoisomerase I inhibitors 110
Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential 110
DNA-Interactive Anticancer Aza-Anthrapyrazoles: Biophysical and Biochemical Studies Relevant to the Mechanism of Action 110
Novel pyrrolo [3,2-f]quinolines: synthesis and antiproliferative activity 110
Interaction between the cytotoxic drug Clerocidin and DNA: evidence for covalent adduct formation 110
Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons 109
Quinolone binding to DNA is mediated by magnesium ions 109
Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates 109
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties 109
Design, synthesis and biological evaluation of TAR and cTAR binders as HIV-1 nucleocapsid inhibitors 107
On the mechanism of action of quinolone drugs 106
From Proteins to Nucleic Acid-Based Drugs: The Role of Biotech in Anti-VEGF Therapy 102
Antiviral 6-amino-quinolones: Molecular basis for potency and selectivity. 101
Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA 101
Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins 101
Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G 99
Aminoacyl-analogues of Mitoxantrone as novel DNA-damaging cytotoxic agents 97
Studies on Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N-1-Vinyl Derivatives 97
In vitro Selection of DNA Aptamers that Bind L-Tyrosinamide 97
Design and synthesis of wm5 analogues as HIV-1 TAR RNA binders 93
Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage 92
Topoisomerase I-targeting drugs: new developments in cancer pharmacology 91
Drugs acting on the beta isoform of human topoisomerase II (p180) 91
Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners 89
Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors 89
Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons 87
Human Thrombin Detection Through a Sandwich Aptamer Microarray: Interaction Analysis in Solution and in Solid Phase. 86
Structure Activity of Topoisomerase I poisons related to Hoechst 33342 86
Further insight into the Zn2+-mediated binding of streptonigrin to DNA 85
Monoclonal antibodies in cancer therapy 83
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative 83
Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin 82
Polyphenolic C-glucosidic ellagitannins present in oak-aged wine inhibit HIV-1 nucleocapsid protein 81
Peptidyl anthraquinones as potential antineoplastic drugs: synthesis, DNA-binding, redox cycling and biological activity 79
2-phenylquinolones as inhibitors of the HIV-1 Tat/TAR interaction. 79
Design, Synthesis and Biological Properties of New Bis(acridine-4-carboxamides) as Anticancer Agents 78
New anti-human immunodeficiency type 1 6-aminoquinolones: mechanism of action 77
2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction 76
Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells 76
Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences 74
Synthesis and evaluation of a bis-3-chloropiperidine derivative incorporating an anthraquinone pharmacophore 74
Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition 73
Mg2+-mediated binding of 6-substituted quinolones to DNA: Relevance to biological activity 73
The evolving world of protein-G-quadruplex recognition: a medicinal chemist's perspective 72
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity 71
DNA topoisomerase-targeted drugs 71
Development of a Multiplex Sandwich Aptamer Microarray for the Detection of VEGF165 and Thrombin 71
Effective DNA inhibitors of Cathepsin G by in vitro selection 70
Preferred interaction of D-peptidyl-anthraquinones with double-stranded B-DNA 70
Protoberberine alkaloids and related compounds as dual inhibitors of mammalian topoisomerase I and II 67
Biologics targeted at TNF: design, production and challenges 66
Anti-HIV quinolones: screening of in vitro activity and recognition of viral nucleic acids targets 65
Multiple in Vitro Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA 65
Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: An in Vitro Study 62
Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor 62
Aptamer   Microarray   Development   for   Human   Thrombin  Detection:  Interaction  Analysis  in  Solution  and  in  Solid  Phase 60
Sequence specific interaction of drugs interfering with topoisomerase-DNA cleavage complex 60
Binding and reactivity towards DNA of PNU-159682, the highly cytotoxic metabolite of nemorubicin 59
Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne 59
Appended Aromatic Moieties in Flexible Bis‐3‐chloropiperidines Confer Tropism against Pancreatic Cancer Cells 59
Synthesis and DNA Cleavage Activity of Bis-3-chloropiperidines as Alkylating Agents 58
null 57
2,6-di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]-acridine-5,7-diones: Novel, potent, cytotoxic, and DNA-binding agents 56
Further insight into the mechanism of action of quinolones 56
DNA-based ligands for Human Cathepsin and medicaments thereof 55
Inhibition of HIV-1 replication by new 6-amino-quinolone compounds 55
Aminoacyl-anthraquinones: DNA-binding and sequence specificity 55
RNA as a drug target 53
Quantitation of camptothecin and related compounds 52
Enzymatic Formation of PEGylated Oligonucleotides 51
IDENTIFICATION OF NEW SARS-COV-2 MAIN PROTEASE INHIBITORS BY AN INTEGRATED IN-SILICO AND IN-VITRO STRATEGY 49
Characterization of the interaction with nucleic acids of the highly cytotoxic oxidative metabolite of the anthracycline nemorubicin by fluorescence quenching assays 49
Small molecules asHIV-1 Tat/TAR complex inhibitors 48
Antracyclines: recent developments in their separation and quantitation 48
DNA binding properties and biological activity of novel sequence-selective peptidyl-anthraquinones 47
Enzymatic PEGylation of oligonucleotides 45
A new inactive conformation of SARS-CoV-2 main protease 45
TOPOISOMERASE TERNARY CLEAVABLE COMPLEXES INDUCED BY INTERCALATORS AND GROOVE BINDERS 43
Quinolinonyl Diketo Acids Bind the Basic Domain of HIV-1 Tat Protein 43
Preparation of PEGylated oligonucleotides by T4 ligase enzymatic mediated coupling. 42
B-CePs as cross-linking probes for the investigation of RNA higher-order structure 42
Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein 42
The pharmaceutical scientist 40
DNA-Binding Properties of Cytotoxic Naphtindolizinedione-Carboxamides Acting as Type II Topoisomerase Inhibitors. A Combined In Silico and Experimental Study 40
Totale 9.173
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Categoria #
all - tutte 29.546
article - articoli 25.930
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 344
selected - selezionate 0
volume - volumi 1.042
Totale 56.862
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019524 0 0 0 0 0 0 0 0 0 0 290 234
2019/20201.928 270 62 41 165 197 176 205 223 186 198 83 122
2020/20211.490 75 106 69 121 63 159 44 156 263 169 172 93
2021/20221.713 45 218 303 97 56 76 116 181 74 26 227 294
2022/20231.390 283 137 55 143 226 151 35 84 156 15 74 31
2023/2024681 36 92 90 80 84 78 75 61 44 41 0 0
Totale 9.810